Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis

Acetyl-L-Carnitine Monograph

Introduction Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized in the human brain, liver, and kidney by the enzyme ALC-transferase. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. ALC, simila...

Acetyl-L-Carnitine in Parkinson’s Disease

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder that is estimated to affect approximately 1% of the population older than 65 years of age (deRijk et al., 2006; Saunders, 2000). PD was first described in 1818 by the British physician J. Parkinson. Before that date, no one had ever described the symptoms of this disease; so many researchers theorize that this patho...

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy